The effects of excessive artificial light, a phenomenon known as light pollution, has direct consequences on retinal health. Constant exposure of light promoted by light pollution may produce retinal degeneration (RD) as a consequence of photoreceptors cells death. It is noteworthy that modern life has extended the environmental illumination with artificial LED lights for several hours to prolong the work schedule, night shift and use of tablets, cellular phones and tv screens for longer times and causing severe effects on the eye. We have characterized the behavior of the neural and glial retina in a pathologic context of light pollution.